Just recently the screen won't wake up via mouse or keyboard and I've had to reboot. I also use a screen saver, set to activate after one hour of inactivity. I've always had my sleep setting set to "never" but set the screen (right above the sleep setting choice) to turn the screen off after two hours. That didn't fix Google Desktop but I've noticed something else has also stopped working.
I've used the reset function after one of Microsoft's updates stopped an old program (Google Destop) from working. I haven't seen this particular problem reported for Windows 10 Home on a Dell XPS 8700.